Keys are weightless and valueless items that allow the player to open otherwise inaccessible doors or terminals (using passwords).
| Name | Found | Opens | Type |
|---|---|---|---|
| Gate Key | On a table in one of the Subway Lines attached to the Access Tunnels found at the start of FROST. | The red interior door found next to the key that leads to feral ghouls eating a corpse. | Key |
| College Square Station Key | On a table inside College Square Station. | Several interior doors including a blue door leading to cash registers, protectrons, an open safe and the Live and Love magazine "Nuke the Man". | Key |
| Chem Stash Key | On a survivor in Hyde Park | A Chem Cooler at the bottom one of the buildings in Hyde Park. (See Note) | Key |
| Service Tunnel Key | Behind a novice locked door in one of the Subway Lines. | Other doors in the same Subway Line. | Key |
| Key of Hunger | In a safe in Medford Memorial Hospital. | Malden Center | Key |
| Key of Fear | Toolbox in Malden Center | Door directly next to it | Key |
| Recon Bunker Access Code 429A | Liberty VI Captain's Quarters on a US Army Remnant | Terminal in Recon Bunker Theta | Password |
| Backdoor Key | Inside a desk inside the FMS Columbia | Opens a door in the Subway Line in Kenmore Station, eventually leads to CIT Concourse. | Key |
| Parsons Front Door Key | On a desk in CIT Concourse. | Parsons State Insane Asylum | Key |